20 601 LEGAL NOTICES 601 LEGAL NOTICES 600 LEGAL 574 SALE LOTS RES. / COMM. / ISLAND WIDE 550 REAL ESTATE FOR SALE FOR SALE – Longwood, St. Elizabeth Prime 3/4 Acre Investment Property (35,325 sq. ft.) – Parent Title Unfinished Subdivision on Naseberry Lane, Santa Cruz 3 Residential Lots: 10,760 sq. ft., 10,760 sq. ft., 13,805 sq. ft. Level to gently sloping land – utilities & road access nearby Ideal for private homes or small development – Minutes from town Photos & Survey Available. Call 876.398.3286 today to arrange a viewing. 19 August, 2025 LOST TITLE APPLICATION NO.: 2464886 OFFICE OF TITLES NOTICE PURSUANT TO SECTION 82 OF THE REGISTRATION OF TITLES ACT (RTA) WHEREAS the applicant(s) in the above stated application has/have declared that the following duplicate Certificate of Title has been lost, I HEREBY GIVE NOTICE that I intend to cancel the said Certificate of Title and issue a new one in duplicate fourteen days after the last publication of this advertisement. Volume: 1398 Folio: 478 Lot: 219 Place: Part of Jubilee Pen and Woodstock Parish: Portland Registered proprietor(s): Audrey Kettle and Tamara Wilson The following transactions lodged with this application will be registered pursuant to section 81 of the RTA: Transfer 2527258 L. Dunbar Deputy Registrar of Titles ------------------------------------- 19 February, 2026 LOST TITLE APPLICATION NO.: 2654560 OFFICE OF TITLES NOTICE PURSUANT TO SECTION 82 OF THE REGISTRATION OF TITLES ACT (RTA) WHEREAS the applicant(s) in the above stated application has/have declared that the following duplicate Certificate of Title has been lost, I HEREBY GIVE NOTICE that I intend to cancel the said Certificate of Title and issue a new one in duplicate fourteen days after the last publication of this advertisement. Volume: 1146 Folio: 867 Place: part of Hellshire called St. Georges Cliff Lot: 45 Parish: St. Catherine Registered proprietor(s): Arthur Oswald Russell and Adel Russell The following transactions lodged with this application will be registered pursuant to section 81 of the RTA: Application to Note Death 2654559 S. MacLean Registrar of Titles ------------------------------------- 27 February, 2026 LOST TITLE APPLICATION NO.: 2693041 OFFICE OF TITLES NOTICE PURSUANT TO SECTION 82 OF THE REGISTRATION OF TITLES ACT (RTA) WHEREAS the applicant(s) in the above stated application has/have declared that the following duplicate Certificate of Title has been lost, I HEREBY GIVE NOTICE that I intend to cancel the said Certificate of Title and issue a new one in duplicate fourteen days after the last publication of this advertisement. Volume: 1113 Folio: 339 Place: Part of Dunrobin Parish: Manchester Registered proprietor(s): Granville McKenzie S. MacLean Registrar of Titles ------------------------------------- ALZHEIMER’S-RELATED BRAIN changes progressed up to 20 times faster in women who also had abnormal levels of a Parkinson’s-related protein, according to a Mayo Clinic study published in JAMA Network Open. The same pattern was not observed in men. THE FINDINGS suggest that when alpha-synuclein – a protein linked to Parkinson’s disease – accumulates alongside Alzheimer’s pathology, it may drive faster disease progression in women. That interaction could help explain a long-standing disparity: women make up nearly two-thirds of people living with Alzheimer’s disease in the U.S. Kejal Kantarci, M.D., a Mayo Clinic neuroradiologist and senior author of the study, uses advanced brain imaging to track Alzheimer’s progression. “Recognizing these sex-specific differences could help us design more targeted clinical trials and ultimately more personalized treatment strategies,” Dr. Kantarci says. “When we see disease-related changes unfolding at dramatically different rates, we cannot keep approaching Alzheimer’s as though it behaves exactly the same way in everyone. Copathologies may impact the disease process.” Alzheimer’s disease is marked by the build-up of tau protein in the brain. Many people along the Alzheimer’s disease continuum also develop abnormal clumping of α-synuclein, a protein associated with Lewy body diseases such as Parkinson’s disease and dementia with Lewy bodies. Tau and α-synuclein occur naturally in the brain. In neurodegenerative diseases, however, these proteins can misfold and clump together, forming abnormal deposits. This pathological build-up disrupts communication between brain cells and contributes to cognitive decline. Researchers set out to determine whether having both abnormal protein buildups alters how the disease progresses and whether that effect differs between women and men. To investigate, the team analysed data from 415 participants in the Alzheimer’s Disease Neuroimaging Initiative, a national research consortium that tracks brain changes over time. Participants underwent cerebrospinal fluid testing to detect abnormal α-synuclein and repeated brain imaging to measure changes in tau accumulation. About 17 per cent of participants showed evidence of abnormal α-synuclein. Among participants with both Alzheimer’srelated pathology and α-synuclein abnormalities, women accumulated tau dramatically faster than men with the same coexisting protein changes. Elijah Mak, Ph.D., first author of the study and a Mayo Clinic neuroimaging researcher, studies how multiple brain pathologies interact and drive disease progression. “This opens an entirely new direction for understanding why women bear a disproportionate burden of dementia,” Dr. Mak says. “If we can unravel the mechanisms behind this vulnerability, we may uncover targets we haven’t considered before.” The researchers are now examining whether these sex-specific effects also appear in patients with dementia with Lewy bodies, where α-synuclein is the primary disease driver rather than a coexisting pathology. The work will help determine whether the observed difference is unique to Alzheimer’s disease or reflects a broader sex-specific vulnerability across neurodegenerative conditions. Mayo Clinic is a nonprofit organization committed to innovation in clinical practice, education and research, and providing compassion, expertise and answers to everyone who needs healing. Alzheimer’s could progress much faster in women with proteins linked to Parkinson’s – study THE WEEKLY GLEANER | APRIL 16 - MAY 14, 2026 | www.jamaica-gleaner.com | CLASSIFIEDS
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